Prolonged cardioprotective effect of pyridostigmine encapsulated in liposomes

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Prolonged cardioprotective effect of pyridostigmine encapsulated in liposomes.

AIMS The purpose of the present work was to investigate the ability of pyridostigmine encapsulated in long-circulating liposomes, to protect against ECG (electrocardiogram) alterations induced by sympathetic stimulation in rats. MAIN METHODS The encapsulation of pyridostigmine was carried out by freeze-thaw and extrusion. Blood pressure and ECG (limb lead II) were monitored in anaesthetized m...

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ژورنال

عنوان ژورنال: Life Sciences

سال: 2010

ISSN: 0024-3205

DOI: 10.1016/j.lfs.2009.10.011